We use cookies to deliver the best possible experience on our website. To learn more, visit our Privacy Policy. By continuing to use this site, or closing this box, you consent to our use of cookies.


Latest Post

May 23, 2017

New Methods in Measuring CCI – Part 1: Helium-Leak for Polymer Systems

Measuring container closure integrity (CCI) of polymer&ndash;based containers and syringes is a challenge. Tracer gas leak detection (i.e., Helium-leak)&mdash;the method endorsed by USP &lt;1207&gt; (<em>Package Integrity Evaluation &ndash; Sterile Products</em>)&mdash;cannot be used directly, because gases permeate polymers. Helium permeates at a very high rate, in part due to its small size. As such, direct use of Helium-leak with a polymer-based system will result in a leak rate above that measured with a glass-based system, that may be misinterpreted as resultant from a non-integral system, but is actually from Helium permeation.
Barb Jacobs

Barb Jacobs

Scientist, Analytical Lab Services

Previous Posts
Nurse holding syringe and vial with patient

May 02, 2017

Safety Always Matters - Especially Patient Safety

Joanne Neizer

Joanne Neizer

Specialist, Technical Customer Service

Scientist in lab

March 31, 2017

Preparing for the Future - Compliance with New USP Chapter <381>

Diego Zurbriggen

Diego Zurbriggen

Supervisor, Lab Leachables

West logo with Diamond

December 29, 2016

West Expands Capabilities in Container Closure Integrity - HVLD

West Pharma

Philomina Albanese

Director, Laboratory Operations


December 21, 2016

West’s Extractables Data Guide    (West EDGe)

West Pharma

Erica Tullo, Ph.D.

Manager, Extractables & Leachables Technology

USP Chapter 1207

July 13, 2016

USP Chapter 1207 Package Integrity Evaluation – Sterile Products

Fran DeGrazio

Fran DeGrazio

VP, Scientific Affairs & Technical Services

Load more