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Material Properties

Suitability of a container/delivery system for a drug product depends upon the chemical/physical properties of the system’s materials of construction (glass, polymer, elastomer)—such as interaction with drug product, gas permeability and durability through temperature cycles. This section presents papers on these and similar topics.

Evaluation of CZ-resin vials for packaging protein-based parenteral formulations.
S.S. Quadry, et al.  International Journal of Pharmaceutics, 252 (1-2), 207-212 (2003)


This article demonstrates that compared to glass, vials comprising Daikyo Crystal Zenith® cyclic olefin polymer provide for significantly less protein binding – and therefore are a viable alternative to glass for biologic drug product packaging/delivery.

Link: http://www.sciencedirect.com/science/article/pii/S0378517302006415

Activation energies of diffusion of organic migrants in cyclo olefin polymer. 
F. Welle.  International Journal of Pharmaceutics, 473, 510-517 (2014)


Discussed is the diffusion of selected organic compounds through cyclic olefin polymer - permeability coefficients are correlated with molecular volume and activation energy of diffusion.

Link: http://www.sciencedirect.com/science/article/pii/S0378517314005286

New Cyclic Olefins. 
Jon H. Schut


This article discusses some of the fundamental properties of cyclic polyolefins, i.e., polymers and co-polymers comprising norborene (bicyclo[2.2.1]hept-2-ene) and ethylene.

Link: http://www.ptonline.com/articles/new-cyclic-olefins

Synthesis of High Performance Cyclic Olefin Polymers (COPs) with Ester Group via Ring-Opening Metathesis Polymerization. 
J. Cui, et al.  Polymers 7 (8), 1389-1409 (2015)


This articles discusses the chemistry of polymerization of cyclic olefin polymers by ring-opening metathesis.

Link:  http://www.mdpi.com/2073-4360/7/8/1389

Chemical Structure and Physical Properties of Cyclic Olefin Copolymers (IUPAC Technical Report). 
Ju Young Shin, et al., Pure and Applied Chemistry (5), 801–814 (2005)


This article examines physical properties of several variants of cyclic olefins co-polymers, including Tg, level of crystallinity, adhesion to metals, surface energy, molecular weight, and 13C NMR.

Link: https://www.degruyter.com/view/j/pac.2005.77.issue-/pac200577050801/pac200577050801.xml

The Preferred Container Material for Parenteral Pharmaceutics. 


This article briefly compares the benefits of cyclic olefin polymers to glass in container/delivery syustems for parenteral drug products.

Link: http://www.chemtech-online.com/P&B/Claudia_oct12.html

Olefin Metathesis. 
R.H. Grubbs.  Tetrahedron 60, 7117–7140 (2004)


This is a review article on ring-opening olefin metathesis polymerization by R.H. Grubbs (California Institute of Technology), 2005 Nobel Laureate in Chemistry.  This type of polymerization is employed in the production of cyclic olefin polymers.

Link:  http://athena.uwindsor.ca/users/j/jlichaa/reference.nsf/6d8ffcfd02afe81e8525730600490ed8/10ff8b04ff3a317885256d88005720f6/$FILE/tet-2004-60-7117%20metathesis%20grubbs.pdf