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Material Properties

Suitability of a container/delivery system for a drug product depends upon the chemical/physical properties of the system’s materials of construction (glass, polymer, elastomer)—such as interaction with drug product, gas permeability and durability through temperature cycles. This section presents papers on these and similar topics.

New Cyclic Olefins. 

Jon H. Schut

Abstract:

This article discusses some of the fundamental properties of cyclic polyolefins, i.e., polymers and co-polymers comprising norborene (bicyclo[2.2.1]hept-2-ene) and ethylene.

Link: http://www.ptonline.com/articles/new-cyclic-olefins


Synthesis of High Performance Cyclic Olefin Polymers (COPs) with Ester Group via Ring-Opening Metathesis Polymerization. 

J. Cui, et al.  Polymers 7 (8), 1389-1409 (2015)

Abstract:

This articles discusses the chemistry of polymerization of cyclic olefin polymers by ring-opening metathesis.

Link:  http://www.mdpi.com/2073-4360/7/8/1389


Chemical Structure and Physical Properties of Cyclic Olefin Copolymers (IUPAC Technical Report). 

Ju Young Shin, et al., Pure and Applied Chemistry (5), 801–814 (2005)

Abstract:

This article examines physical properties of several variants of cyclic olefins co-polymers, including Tg, level of crystallinity, adhesion to metals, surface energy, molecular weight, and 13C NMR.

Link: https://www.degruyter.com/view/j/pac.2005.77.issue-/pac200577050801/pac200577050801.xml


The Preferred Container Material for Parenteral Pharmaceutics. 

Abstract:

This article briefly compares the benefits of cyclic olefin polymers to glass in container/delivery syustems for parenteral drug products.

Link: http://www.chemtech-online.com/P&B/Claudia_oct12.html


Olefin Metathesis. 

R.H. Grubbs.  Tetrahedron 60, 7117–7140 (2004)

Abstract:

This is a review article on ring-opening olefin metathesis polymerization by R.H. Grubbs (California Institute of Technology), 2005 Nobel Laureate in Chemistry.  This type of polymerization is employed in the production of cyclic olefin polymers.

Link:  http://athena.uwindsor.ca/users/j/jlichaa/reference.nsf/6d8ffcfd02afe81e8525730600490ed8/10ff8b04ff3a317885256d88005720f6/$FILE/tet-2004-60-7117%20metathesis%20grubbs.pdf