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Container Closure Integrity of Rubber-stoppered Glass and Plastic Vials Stored at -80°C and in Dry Ice

Comparing CCI and performance of CZ vials with rubber stoppers at low temperatures.
An increasing number of pharmaceuticals including vaccines, stem cells and proteins require cold storage to maintain efficacy prior to use. However, the ability to maintain container closure integrity (CCI) during cold storage is still not completely understood.

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