Previous Blogs

Blue West logo with Diamond

By Global Communications

March 11, 2015

West Pharmaceuticals will participate in two poster presentation sessions at the Parenteral Drug Association (PDA) Annual Meeting, taking place March 16-18, 2015 in Las Vegas. During the meeting, West will also showcase innovations in integrated drug packaging and delivery systems that help ensure the quality, safety and efficacy of injectable drug products for pharmaceutical and biotechnology manufacturers worldwide at booth #405.

By Lloyd Waxman and Vinod Vilivalam

May 29, 2012

Lloyd Waxman, Harold Murray and Vinod Vilivalam

 
ABSTRACT
 
Purpose: The shipment and storage of biopharmaceuticals in prefilled syringes (PFS) places new demands on PFS performance. Studies compared package integrity of glass and plastic PFS: piston movement was evaluated under reduced pressures to simulate transport by air in non-pressurized holds, and container closure integrity was tested on PFS that had been frozen or frozen and thawed, since some biopharmaceuticals are stored and transported in the frozen state. Piston release and travel forces were also measured in plastic PFS since in order to be competitive with siliconized glass PFS, the functional characteristics of plastic PFS must meet or exceed the criteria established for glass PFS.

By Amy Miller & Jennifer Riter

April 09, 2012

Dr. Heike Kofler, Amy Miller, Jennifer Riter
West Pharmaceutical Services, Inc.

One of the critical success factors for packaging lyophilized drugs is protection against product degradation caused by moisture. Moisture can be introduced into a lyophilized drug product cake from the elastomeric stopper and from the atmospheric headspace; it can also permeate through the stopper, a process known as moisture transmission.

By Tibor Hlobik

March 14, 2012

Tibor Hlobik, Director, Prefillable Solutions and Technologies
Mike Gills, Customer Technical Support Process Engineer

Growth in biopharmaceutical therapeutics is leading innovation with prefillable syringe systems. These complex sensitive drug products require highly inert primary packaging materials for improved stability and delivery in perfect quality for reduced safety risk. This poster will provide a quality comparison of primary prefillable syringe options including glass, coatings/laminates and cyclic olefin polymers, and highlight the findings of a case study comparing 1mL long syringe attributes.

By Amy Miller & Jennifer Riter

February 17, 2012

Amy Miller and Jennifer Riter

Extractables from elastomeric components become an issue even before a pharmaceutical drug makes contact with the elastomeric component. The suitability of the elastomer and the drug product needs to be taken into consideration at the development stage of the packaging and delivery system for the drug product. The potential for an extractable to leach into the drug product and the impact that leachable will have on the drug’s stability, efficacy and toxicity needs to be scientifically evaluated.

By Global Communications

January 09, 2012

J. Riter, A. Janssen, D. Engels

Cracking of elastomeric needle shields and tip caps is a costly problem for pharmaceutical manufacturers. Cracked components can cause leaks that can result in loss of drug potency and sterility and may lead to a safety risk for the person administering the drug and the patient. This cracking has been attributed to ozone degradation of the elastomer formulations.