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The manufacture of polymer containers for parenteral drug products differs from that of glass and elastomers and must combine the common manufacturing methods below to meet the needs of the pharmaceutical market.
Common methods for forming thermoplastic polymer components are:
Conical vials, syringes and cartridges comprising Daikyo Crystal Zenith® cyclic olefin polymer can be produced with a standard injection molding process. But, to allow for release from an injection mold, a component cannot possess features such as an overhang or undercut, thus preventing critical features such as vial shoulder. Therefore, for standard Daikyo Crystal Zenith vials, a hybrid process is needed – one comprising both injection and blow aspects. For the hybrid process, melted polymer is injected into the mold around a core pin, creating a preform with the appropriate neck and flange dimensions. The remaining melted polymer around the core pin is then blown with air to form the complete vial. This hybrid method enables a traditional shape having the very tight tolerances of injection molding, in particular at the flange –minimizing variation at the crucial vial stopper interface and helping to ensure good container closure integrity.
West’s commitment to the safe and efficient delivery of drug products involves not only designing the right components, but also manufacturing them to rigorous standards. To learn more about West products, please visit the Knowledge Center or contact a Technical Account Representative.
Daikyo Crystal Zenith® is a registered trademark of Daikyo Seiko, Ltd. Crystal Zenith® technology is licensed from Daikyo Seiko, Ltd.
Christa Jansen-Otten and Dr. Heike Kofler will moderate the ”Prefillable Glass Syringe and the Appropriate Pharmaceutical Rubber Components: Processing, Packaging, Innovations,” at the 53° SIMPOSIO AFI in Rimini, Italy, on June 12-14, 2013.
On June 15, 2016, West’s contract manufacturing division—formerly known as The Tech Group—attended Medical Design & Manufacturing (MD&M) East in New York City. This annual event is especially insightful, as it offers access to six additional industry expos–EastPack, ATX (Automation Technology) East, Atlantic Design & Manufacturing, PLASTEC East, HBA Global, and Quality Expo. Show attendees discovered the latest innovations, new materials, and state-of-the-art manufacturing processes from among 900 suppliers.
Binghuan Cao, Sr. Tech Support, Maintenance, China, has worked at West for 12 years. He is a highly motivated, philanthropic activist for West without Borders activities and local community services. Binghuan has been involved in West Without Borders activities in China for the past 10 years. In addition to donating, he has volunteered as a representative for West in support of local schools and community organizations.
Cell-based therapies have emerged as a revolutionary approach in the field of regenerative medicine and as an anti-cancer therapeutic modality, offering potential treatments for a range of diseases. As the demand for cell-based therapies continues to grow, it is crucial to explore the current and future fill-finish packaging strategies to ensure the safety, efficacy, and accessibility of these therapies. Understanding the advantages and challenges associated with different modes for cell therapy packaging will allow drug manufacturers to choose a suitable system.
Camp Victory, which is located in Millville, Pennsylvania, operates camps for children with special needs and children who live with chronic health disadvantages including spina bifida, autism and cancer. In 2007, West donated the funding and manpower needed to build a wheel-chair accessible tree house and has maintained an affiliation with the camp ever since. So when Camp Victory sent out a call for fundraising as part of its 2013 Corporate Sponsorship Program, West was pleased to become a Corporate Partner with a donation of $25,000.
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