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Surface Properties & Enhancements

Surfaces of a drug product container/delivery systems are often modified to enhance performance by: (a) reducing interaction with drug product, (b) retarding migration of leachables into drug product, and (c) facilitating delivery (e.g., easier plunger movement). Typically modification is a fluoropolymer (West FluoroTec® branded products) or polysiloxane (B2-Coating technology) coating. This section presents papers on surface modification technology and resultant effects.

Introduction to Fluoropolymers. 

S. Ebnesajjad (FluoroConsultants Group, LLC)

Abstract:

This article reviews the structures, syntheses, and chemical/physical properties of many different types of fluoropolymers, e.g. tetrafluoroethylene (PTFE) and ethelyene tetradloroethylene (ETFE).

Link: http://www.fluoroconsultants.com/sitebuildercontent/sitebuilderfiles/introductiontofluoropolymers.pdf


Introduction to Silicone Chemistry. 

A. Colas

Abstract:

This article discusses briefly the different types of silicone polymers, and how they are synthesized.

Link: http://www.dowcorning.com/content/publishedlit/Chapter1_silicone-chemistry-introduction.pdf


Silicones in Medical Applications. 

X. Thomas

Abstract:

This article discusses in detail the chemical/physical properties (e.g., very low surface energy) of silicone polymers, and why these properties enable utility in pharmaceutical applications.

Link: http://www.dowcorning.com/content/publishedlit/Chapter17.pdf


Silicones in Coatings. 

T. Easton

Abstract:

This article discusses in general the reasons that the properties of silicone polymers make them suitable for coatings applications.

Link: http://www.dowcorning.com/content/publishedlit/Chapter7.pdf


Surface Tension of Polymers. 

A. Agrawal

Abstract:

Utility of fluoropolymers and siloxane polymers in the pharmaceutical industry is based in large part on low surface tensions.  This presentation reviews the fundamental science of surface tension.

Link: http://web.mit.edu/nnf/education/wettability/summerreading-2005short.pdf

 

 

 

 

FluroTec® is a registered trademark of West Pharmaceutical Services, Inc. in the United States and of an affiliated company in other jurisdictions.

B2-coating technology is licensed from Daikyo Seiko, Ltd.