Surfaces of a drug product container/delivery systems are often modified to enhance performance by: (a) reducing interaction with drug product, (b) slowing migration of leachables into drug product, and (c) facilitating delivery (e.g., easier plunger movement). Typically modification is a fluoropolymer (West FluroTec® branded products) or polysiloxane (B2-Coating technology) coating. This section presents papers on surface modification technology and resultant effects.
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This research presents multiple methods which may be used in a complementary manner to understand surface chemistry and the interaction of drug product with package system components. Employing these methods can help to ensure selection of the right package system and protect patient safety.
This article reviews the structures, syntheses, and chemical/physical properties of many different types of fluoropolymers, e.g. tetrafluoroethylene (PTFE) and ethelyene tetradloroethylene (ETFE).
<p><em>S. Ebnesajjad (FluoroConsultants Group, LLC)</em></p>
<p>This article discusses in detail the chemical/physical properties (e.g., very low surface energy) of silicone polymers, and why these properties enable utility in pharmaceutical applications.</p>
Utility of fluoropolymers and siloxane polymers in the pharmaceutical industry is based in large part on low surface tensions. This presentation reviews the fundamental science of surface tension.
FluroTec® technology is licensed from Daikyo Seiko, Ltd.
B2-Coating technology is licensed from Daikyo Seiko, Ltd.