Surface Properties and Enhancements
Surfaces of a drug product container/delivery systems are often modified to enhance performance by: (a) reducing interaction with drug product, (b) retarding migration of leachables into drug product, and (c) facilitating delivery (e.g., easier plunger movement). Typically modification is a fluoropolymer (West FluroTec® branded products) or polysiloxane (B2-Coating technology) coating. This section presents papers on surface modification technology and resultant effects.
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Shares differences between B2 coating and silicone oil, and considerations to keep in mind when choosing between them.
The differences between B2 and FluroTec® and their applications are discussed.
Study done to compare extractables between FluroTec® and non-laminated stoppers
This article reviews the structures, syntheses, and chemical/physical properties of many different types of fluoropolymers, e.g. tetrafluoroethylene (PTFE) and ethelyene tetradloroethylene (ETFE). <p><em>S. Ebnesajjad (FluoroConsultants Group, LLC)</em></p>
This article discusses briefly the different types of silicone polymers, and how they are synthesized. <p><em>A. Colas</em></p>
<p>This article discusses in general the reasons that the properties of silicone polymers make them suitable for coatings applications.</p> <p><em>T. Easton</em></p>
<p>This article discusses in detail the chemical/physical properties (e.g., very low surface energy) of silicone polymers, and why these properties enable utility in pharmaceutical applications.</p> <p><em>X. Thomas</em></p>
Utility of fluoropolymers and siloxane polymers in the pharmaceutical industry is based in large part on low surface tensions. This presentation reviews the fundamental science of surface tension. <p><em>A. Agrawal</em></p>
FluroTec® technology is licensed from Daikyo Seiko, Ltd.
B2-Coating technology is licensed from Daikyo Seiko, Ltd.