When Glass Vials Fail At Low Temperatures, Consider A Cyclic Olefin Polymer System.
W. Winters. Pharmaceutical Online (July 25, 2017)
This article describes the many benefits of Daikyo Crystal Zenith® cyclic olefin polymer versus glass for low-temperature storage of drug products.
Container system for enabling commercial production of cryopreserved cell therapy products.
E. Woods, et al. Regen. Med., 5 (4), 659-667 (2010)
This article demonstrates that vials comprising Daikyo Crystal Zenith® cyclic olefin polymer are well-suited to cryogenic storage/transport of cell therapy products.
Evaluation of CZ-resin vials for packaging protein-based parenteral formulations.
S.S. Quadry, et al. International Journal of Pharmaceutics, 252 (1-2), 207-212 (2003)
This article demonstrates that compared to glass, vials comprising Daikyo Crystal Zenith® cyclic olefin polymer provide for significantly less protein binding – and therefore are a viable alternative to glass for biologic drug product packaging/delivery.
Activation energies of diffusion of organic migrants in cyclo olefin polymer.
F. Welle. International Journal of Pharmaceutics, 473, 510-517 (2014)
Discussed is the diffusion of selected organic compounds through cyclic olefin polymer - permeability coefficients are correlated with molecular volume and activation energy of diffusion.
New Cyclic Olefins.
Jon H. Schut
This article discusses some of the fundamental properties of cyclic polyolefins, i.e., polymers and co-polymers comprising norborene (bicyclo[2.2.1]hept-2-ene) and ethylene.
Synthesis of High Performance Cyclic Olefin Polymers (COPs) with Ester Group via Ring-Opening Metathesis Polymerization.
J. Cui, et al. Polymers 7 (8), 1389-1409 (2015)
This articles discusses the chemistry of polymerization of cyclic olefin polymers by ring-opening metathesis.
The Preferred Container Material for Parenteral Pharmaceutics.
This article briefly compares the benefits of cyclic olefin polymers to glass in container/delivery syustems for parenteral drug products.
R.H. Grubbs. Tetrahedron 60, 7117–7140 (2004)
This is a review article on ring-opening olefin metathesis polymerization by R.H. Grubbs (California Institute of Technology), 2005 Nobel Laureate in Chemistry. This type of polymerization is employed in the production of cyclic olefin polymers.