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The manufacture of polymer containers for parenteral drug products differs from that of glass and elastomers and must combine the common manufacturing methods below to meet the needs of the pharmaceutical market.
Common methods for forming thermoplastic polymer components are:
Conical vials, syringes and cartridges comprising Daikyo Crystal Zenith® cyclic olefin polymer can be produced with a standard injection molding process. But, to allow for release from an injection mold, a component cannot possess features such as an overhang or undercut, thus preventing critical features such as vial shoulder. Therefore, for standard Daikyo Crystal Zenith vials, a hybrid process is needed – one comprising both injection and blow aspects. For the hybrid process, melted polymer is injected into the mold around a core pin, creating a preform with the appropriate neck and flange dimensions. The remaining melted polymer around the core pin is then blown with air to form the complete vial. This hybrid method enables a traditional shape having the very tight tolerances of injection molding, in particular at the flange –minimizing variation at the crucial vial stopper interface and helping to ensure good container closure integrity.
West’s commitment to the safe and efficient delivery of drug products involves not only designing the right components, but also manufacturing them to rigorous standards. To learn more about West products, please visit the Knowledge Center or contact a Technical Account Representative.
Daikyo Crystal Zenith® is a registered trademark of Daikyo Seiko, Ltd. Crystal Zenith® technology is licensed from Daikyo Seiko, Ltd.
Take an in-depth look at the science behind containment & delivery of injectable medicines in the West Knowledge Center.