Ophthalmic Drug Delivery Challenges for Intravitreal Injections

Ophthalmic packaging solutions designed to help you meet

stringent standards while ensuring accurate and safe drug delivery

NovaPure® 0.5 mL Plunger

  • West’s highest quality component, built on the proven 4023/50 formulation in the NovaPure portfolio
  • No free silicone oil, ensuring excellent compatibility and consistent performance in sensitive drug applications
  • FluroTec™ barrier film minimizes interactions between the drug product and the elastomer
  • Low endotoxins and particles to enable alignment to US, FDA, and EU Ophthalmic regulations

Daikyo Crystal Zenith® (CZ) 0.5mL Luer Lock Syringe

  • Made with cyclic olefin polymer, providing a break-resistant, low extractables/leachable, high clarity, lightweight, and sterile-ready solution
  • Ultra‑clean performance with no silicone oil applied for functionality, ensuring exceptional safety for silicone‑sensitive therapies.
  • FluroTec™ barrier film helps reduce contamination risk
  • Meets USP <789> particulate and endotoxin standards for intravitreal injections

Learn more by downloading our product information sheet

The Challenges Most Face

Silicone Contamination Risk

Silicone is widely used as a lubricant in drug delivery systems to ensure smooth plunger movement. However, in ophthalmic applications, silicone migration can lead to particulate contamination, drug interaction, and uneven distribution, creating risks of patient vision issues, regulatory delays, and end-of-line rejects.

Particulate & Endotoxin Contamination

For ophthalmic applications, the regulations for particulates and endotoxins are more stringent. Each step in the filling process introduces the potential of foreign particles Most drug delivery systems and components were not specifically designed for the tighter regulatory and quality requirements of the ophthalmic space. What works in other spaces may not work for today's ophthalmic drugs.

Dosage Accuracy

Ophthalmic treatments require precise dosing, where even small variations can impact patient safety and drug efficacy. The break-loose and glide force performance of your syringe is an important factor in consistent delivery of the right dose. Most syringes are not designed to meet the tolerances you require, or the plunger does not have the right shape for maximizing drug utilization.

Are you facing these challenges?
Learn more about overcoming ophthalmic drug delivery challenges
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NovaPure® and The Clear Solution for Ocular Patient Safety™ are trademarks or registered trademarks of West Pharmaceutical Services, Inc. in the United States and other jurisdictions. Crystal Zenith® is a registered trademark of Daikyo Seiko, Ltd. and is used under license.