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There are two major types of prefillable syringe systems available:
Traditionally, a prefillable syringe barrel has been made from glass tubing. These glass tubes are transformed by heat into the barrel that is used to hold the drug product. Syringe manufacturers typically form and process the glass and purchase the complementing elastomeric components (e.g., plungers, tip caps, needle shields) that complete the primary package from an elastomeric closure manufacturer.
The benefits of glass systems include:
There are, however, drawbacks:
Plastic-based syringe systems are gaining acceptance because of their benefits compared to glass systems. The Japanese market, which is well known for its high quality, has transitioned over 50% of its syringes to plastic because of its superior performance.
The most widely used prefillable plastic syringe systems are manufactured from cyclopolyolefin (COP) resin. These systems are manufactured to very high quality standards and to tight dimensional tolerances. As there are many types of plastics, it is imperative to understand the unique characteristics of the plastic syringe system being evaluated because the package choice is critical in ensuring the long-term success of a pharmaceutical or biopharmaceutical drug product.
The benefits of plastic-based systems include:
To learn more about prefillable syringe systems, click here.