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The Knowledge Center

provides an in-depth look at the science behind many of the industry’s top concerns regarding containment and delivery of injectable medicines.


June 19, 2018

Coring and Fragmentation of Elastomer Components – Some Fundamentals

The coring and fragmentation of elastomer components used in containment of parenteral drug products continues to be a challenge. Many factors influence these phenomena, so it is critical that a pharmaceutical manufacturer understands how a vial system will be used, for example: what is the recommended needle gauge; is it single- or multi-dose; could spikes, vial adapters or closed system transfer devices be used. Cores and fragments can be generated by needle penetration of the elastomer components. Cores are formed by the needle cannula cutting the elastomer &ndash; ordinarily they are cylindrical. Fragments are formed via an abrasion phenomenon of the needle penetration &ndash; shapes are irregular. <br />
Fran DeGrazio

Fran DeGrazio

VP, Scientific Affairs and Technical Services

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Featured Event

2018 Workshop on Protein Aggregation and Immunogenicity

July 31, 2018 - August 02, 2018
7:00 a.m. - 5:00 p.m.
Breckenridge, Colorado

Visit West’s booth at the Workshop on Protein Aggregation and Immunogenicity from July 31 to August 2! Learn more about Daikyo Crystal Zenith® solutions that offer glass-like transparency, superior break resistance and low risk of chemical interactions. Daikyo Crystal Zenith Containment & Delivery Systems can also help avoid issues associated with glass, including delamination and particulates.

BioMed Device Event Details
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