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August 14, 2018

Protein Adsorption to Primary Container Systems - Why Is It Important?

Primary container systems for storage and delivery of protein and peptide drugs (i.e., biologics), including vials and prefillable syringes, are typically made of glass or polymer, and include an elastomeric component (stopper or plunger). Proteins adsorb to most surfaces. Generally, the resultant loss of drug is not an issue since the amount adsorbed is on the order of 2-10 mg/m2, or not more than approximately 5 µg per 2 mL vial, or 13 µg per 5 mL vial.</br>
Lloyd Waxman

Lloyd Waxman Ph.D.

Lead Research Scientist, Insights Lab

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