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Packaging material selection is a key consideration in reducing particle loads. Silicone free prefilled systems such as the Daikyo Crystal Zenith® Insert Needle Syringe, eliminate one of the largest sources of subvisible particles and eliminate the risk of clinical complications tied to the injection of silicone oil droplets into the eye. Since proteins can potentially adsorb at any interface, eliminating silicone oil may also lead to a reduction in protein particles. Inert Cyclic Olefin Polymer (COP) container surfaces themselves may offer advantages over glass to reduce the risk of protein aggregation.1,2 Finally, FluroTec® barrier film-coated elastomers such as NovaPure® components reduce leachables that could potentially cause stability issues with a protein drug.
To find out more about the packaging and delivery options available for ophthalmic drug delivery, contact your Technical Customer Service (TCS) representative.
For more information please join West at the PharmaED 2019 Pre-Filled Syringes & Auto-Injectors Forum, February 27–28, 2019, at the Metro Meeting Center in Boston, MA.
FluroTec® and NovaPure® are registered trademarks of West Pharmaceutical Services, Inc., in the United States and other jurisdictions. FluroTec® technology is licensed from Daikyo Seiko, Ltd.Crystal Zenith® is a registered trademark of Daikyo Seiko, Ltd. Daikyo Crystal Zenith® technology is licensed from Daikyo Seiko, Ltd.