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The advantages include:
And because coefficients of thermal expansion match more closely between rubber/polymer than between rubber/glass, there is lower risk of loss of container closure integrity (CCI) at cryogenic temperatures. In view of the advantages of polymers, the obvious question concerns the best polymer. The requirements are:
These points were considered in detail in the presentation: "Challenges in Low-Temperature Storage of Cell Therapy Drug Products at PepTalk 2020." Considered also were the O2 and CO2 permeability rates of COP-based containment systems, from room temperature down to -80oC and -180oC. Rates were for the first time quantified; and they were demonstrated in fact to be low. Moreover, these systems demonstrated excellent CCI down to -180oC. These data indicate that COP-based systems should be suitable for a wide range of drug products stored at cryogenic temperatures. For more, contact an Account Manager or Technical Customer Service (TCS) representative.
Crystal Zenith® is a registered trademark of Daikyo Seiko, Ltd. Daikyo Crystal Zenith® technology is licensed from Daikyo Seiko, Ltd.