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March 13, 2020

Multiple Benefits of Elastomeric Closures with FluroTec® Barrier Film

Historically, finding suitable containers for complex protein drug products has been difficult, since interaction with elastomeric closures can result in particle formation. These particles indicate an underlying change within the drug product, undermining integrity and risking patient safety. The correlation of silicone coatings with protein aggregation has made some wary of their use; however, an elastomeric closure with no coating or film can be difficult to process. Another concern is that leachables originating from the elastomeric closure can induce particle formation.
Gabrielle Gehron

Gabrielle Gehron

Associate Technical Account Specialist, TCS

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