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August 05, 2021

Preventing Residual Moisture in Lyophilization Stoppers

Some pharmaceutical substances, such as proteins, monoclonal antibodies, enzymes, and vaccines, are unstable in solution. They can degrade, for example by enzymatic or hydrolytic reactions. Lyophilization (also called freeze-drying) is the most common approach to address this.* Lyophilization is the process of dehydrating a material at low temperature and reduced pressure. Absent water, the rates of degradative enzymatic/hydrolytic processes are reduced substantially, and thus drug product stability is improved.
Birgit Mueller

Birgit Mueller-Chorus, Ph.D.

Manager, TCS, Components Development

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