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West’s scientists have examined this issue in detail and reported their findings in the just-published technical report: Ingress of Gases into Cyclic Olefin Polymer Vial Based Container Closure Systems at -80oC. Focus was on systems comprising Daikyo Crystal Zenith® cyclic olefin polymer (COP) vials. It was demonstrated experimentally that for either refrigeration or storage on dry ice, rate of ingress of oxygen and carbon dioxide is very low and quantifiable. Studies such as these enable customers to make proper risk assessments, and thus select the right vial containment systems.
In view of these studies, and the inherently better fracture resistance of polymers, COP-based vial containment systems are an excellent choice for many gene therapy drug products. For more, contact an Account Manager or a Technical Customer Service representative.
Crystal Zenith® is a registered trademark of Daikyo Seiko, Ltd. Daikyo Crystal Zenith® technology is licensed from Daikyo Seiko, Ltd.