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Evaluation of End-Over-End Rotation/Agitation of Protein Solutions in Prefilled Syringes Made from Glass or Plastic as a Preliminary Indicator of Protein Aggregation

This study looks at the effect of mild agitation on protein aggregation in prefilled syringes made of either siliconized glass or silicone-free plastic.
The growing use of proteins as therapeutics has focused attention on the need to maintain the stability of these molecules during storage and shipment under a variety of environmental conditions.

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