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As drug manufacturers aim for higher safety standards and enhanced patient care, controlling the drug product at the point-of-use in a hospital or clinical environment remains a significant challenge. The method of vial access often varies, increasing the risk of adverse patient outcomes, such as stopper cores or fragments entering the drug product. If injected, these fragments can lead to cardiovascular events and other complications. Several factors contribute to stopper coring and fragmentation in the field, primarily influenced by the technique of the practitioner and the properties of the elastomeric closure.

Sanjeev Seenath

July 09, 2025

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Previous Blogs

Capping Reading Between the Guidelines

By Michelle Deutsch

July 14, 2015

As members of the pharmaceutical community, we’re often keenly aware of regional regulatory differences. But it’s just as useful to focus on points of harmony, whether these are well-established, emerging, or implicit in regulatory and industry feedback.

West Launches High-Quality Flip-Off Plus RU Seals

By West's Global Communications Team

February 16, 2015

West is pleased to announce the availability of a new sterile drug vial seal, the Flip-Off^® Plus^RU seal. Part of West’s Flip-Off® seal product family, these new ready-to-use seals help pharmaceutical and biopharmaceutical manufacturers protect the safety and integrity of their drug products while meeting regulatory requirements for increased drug cleanliness and safety.

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Films and Coatings

Pharmaceutical Packaging Components

Prefillable Systems

Self Injection Devices

Vial Containment Solutions

Washing and Sterilization

Reconstitution and Transfer Devices

Select a sub-category to view results

Analytical Lab Services

Contract Manufacturing

Fill-Finish

Regulatory Support

Select a sub-category to view results

Cell and Gene Therapy Packaging

Drug Development Process

Regulatory Challenges

Transitioning to Combination Products

Select a sub-category to view results

Corporate Development

ESG/Sustainability

One West Team (Employee Culture)

Our Culture of Giving (Philanthropy)

Research and Development