Blogs

Harold Murray, Project Engineer, and Robert Froio, Intern, West Pharmaceutical Services, Inc.

Flange strength and dimensional variability are critical attributes when designing or selecting an auto-injector device to use in conjunction with a 1mL long syringe. Studies were performed to compare these attributes using Daikyo Crystal Zenith® (CZ) 1mL long syringes and glass 1mL long syringes.

Patrick Curran¹, Vinod Vilivalam¹, Suzanne Kuiper² and Derek Duncan^2
1West Pharmaceutical Services, Inc. and ²Lighthouse Instruments B.V.

An increasing number of pharmaceuticals including vaccines, stem cells and proteins require cold storage to maintain efficacy prior to use. However, the ability to maintain container closure integrity (CCI) during cold storage is not completely understood.

A scientific poster by: Clara Goodfield, Eugene Polini, Amy Miller and Wayne Curry

The ideal sterilization process destroys all microorganisms rapidly with minimal adverse impact on the chemical and physical properties of the elastomeric closure. Developing and validating an acceptable sterilization process is critical to the drug product quality. This study served to help understand the potential deterioration of physical and chemical properties, the possible impact to functionality and the potential changes to the extractable/leachable profile as a result of sterilization