We apologize your item could not be found. Not all items are listed on our website. Please contact your account manager for details regarding your searched item.
Material number (eg: xxxxxxxxxxx) no space or hyphen needed.
No Results Found
The first thought that you may have when you hear the word “rubber” is natural rubber – a poly-isoprene-based polymer, which has as its origination the latex fluid drawn from rubber trees (most prominently in Indonesia and Malaysia). Although natural rubber has been used in the past for pharmaceutical applications, potential issues with latex allergies resultant from proteins from the original latex, have led to the almost complete adoption of synthetic rubber.
One of the main synthetic rubber types currently used for pharmaceutical applications is halobutyl (CIIR: chlorobutyl rubber, and BIIR: bromobutyl rubber) – developed in the 1950s and 1960s. The monomers comprising halobutyl rubbers are based on isobutylene (~98%) and isoprene (~2%) – both derived from oil. Halobutyl rubbers combine low gas permeability, good durability on exposure to moisture and heat, and good chemical stability. This makes them an ideal match for pharmaceutical closures, such as stoppers or plungers. The halobutyl rubber is, however, just one component of a complete rubber formulation.
The base rubber comprises the major amount, of course; in addition there are for instance fillers, pigments, curing agents, accelerators, activators and plasticizers. A formulation is designed very carefully to give the right properties (e.g., hardness, color, extractables and leachables profile) – in order to give the right performance. Over time, numerous formulations have been developed by West and optimized for maximum functional and chemical performance – especially in regard to extractables and leachables profiles.
Technical Customer Support (TCS) helps customers not only in choosing the optimal rubber formulation, but also with extractables and leachables information. For more, contact a TCS representative, or visit the West Knowledge Center.
Patrick Curran<sup>1</sup>, Vinod Vilivalam<sup>1</sup>, Suzanne Kuiper<sup>2</sup> and Derek Duncan<sup>2<br></sup><sup>1</sup>West Pharmaceutical Services, Inc. and <sup>2</sup>Lighthouse Instruments B.V.<p>An increasing number of pharmaceuticals including vaccines, stem cells and proteins require cold storage to maintain efficacy prior to use. However, the ability to maintain container closure integrity (CCI) during cold storage is not completely understood. </p>
<p>We are very pleased to introduce our newly redesigned and enhanced website: <a href="https://www.westpharma.com">www.westpharma.com</a>. </p><p>Our commitment to customers guides everything that we do – and our website is no different. The new and improved site offers a fresh look with easy navigation, mobile optimization and expanded digital capabilities to improve the customer experience.</p>
<p><em>Part 4 of the Good Supply Practices Series</em></p><p><em>West is pleased to welcome guest blogger Dr. Marla Phillips, Director, </em><em><span style="text-decoration: underline;">Xavier Health</span></em><em>, Xavier University. This is the fourth installment in a four-part series on supply chain management.</em></p><p>There is strong recognition that human factors play a large role in how the supply chain operates (as with everything else). Success and positive impact cannot be attained without simultaneously addressing what drives human behavior in this space. </p>
Packaging components are an integral part of a drug product. Selecting the right packaging system is not trivial--it can impact patients' health, operational efficiency, drug compatibility and drug stability. A good container closure system includes a glass or polymer vial, an elastomer stopper and an aluminum seal.
The Packaging Academy has been organized by West in Asia Pacific for the past 5 years, beginning in 2015, and serves as a valued training platform for our customers in injectable packaging both in the areas of containment and delivery systems.
English
Chinese
