We apologize your item could not be found. Not all items are listed on our website. Please contact your account manager for details regarding your searched item.
Material number (eg: xxxxxxxxxxx) no space or hyphen needed.
No Results Found
The process of crimping an aluminum seal onto a pre-stoppered vial should not be overlooked or underemphasized. Within the pharmaceutical industry, there is a need for an elegant and effective seal not only from the cosmetic perspective, but also more importantly, because of the correlation between seal quality and container closure integrity. Even in laboratory settings and during early-stage evaluations of a drug product and containment system, reliable, robust and consistent crimped seals are necessary.
Historically, issues can arise due to unoptimized crimping processes or equipment. Often the use of jaw-type crimping devices can generate defects due to the dimensions of the jaw head not being appropriate for the vial, stopper or seal. Also, if the downward pressure onto the vial is not appropriate or uniform, a defect can result from the jaws prematurely squeezing the skirt prior to being in the desired position of the vial crown. If a jaw-type crimper must be used, the recommendation is to have a unique jaw-head change part for each combination of vial, stopper and seal. In addition, downward pressure must be optimized.
West does not recommend the use of jaw-type crimpers. Disc-style crimping offers a more consistent, commonly used method. In this method, a pressure block applies an appropriate and uniform pressure onto the vial, stopper and seal. A disc then gently and consistently tucks the aluminum under the flange of the vial crown, securing the seal. Properly sealed vials are essential as they help to achieve that highest objective – patient safety.
Courtesy of Bausch + Ströbel
For additional information regarding industry available disc-style crimpers, such as bench-top units or large-scale machines, please contact your Account Manager or Technical Customer Service Representative.
Patrick Curran<sup>1</sup>, Vinod Vilivalam<sup>1</sup>, Suzanne Kuiper<sup>2</sup> and Derek Duncan<sup>2<br></sup><sup>1</sup>West Pharmaceutical Services, Inc. and <sup>2</sup>Lighthouse Instruments B.V.<p>An increasing number of pharmaceuticals including vaccines, stem cells and proteins require cold storage to maintain efficacy prior to use. However, the ability to maintain container closure integrity (CCI) during cold storage is not completely understood. </p>
Have you ever wanted to fly among the clouds? To rapidly deploy apps or manage IT services with greater flexibility? To support real-time analytics across all types of data from email to ERP? West IT is leveraging cloud computing to help realize those goals. West began its journey to the cloud several years ago by looking first at cloud service offerings for all new IT services. Such services allow IT to satisfy the strategic goal of cost-effectively enabling high availability of IT services in a more mobile and globally competitive world.
West team members from our facility in Clearwater, FL recently concluded their 2018 West without Borders* campaign. West without Borders is West’s employee-led fundraising initiative, where each of its more than 50 locations worldwide selects a charity to support, then coordinates fundraising activities to raise donations. <br />
Mobile technology can be a great time saver, or a time-sink, depending on the apps you’re using and how you use them. At West, we recognize that it’s important to choose your apps wisely. As we begin to build our Mobile App Store, we are focused on applications that enable us to be more connected and forward-looking – foundations for being successful in a globally competitive world. Since there’s an app for almost every purpose these days, we believe that it’s critical to reduce distraction by focusing on apps that will improve productivity wherever our work takes us.
“There is no disease so rare that it does not deserve attention.” This statement from Orphanet, a portal for rare diseases and orphan drugs, makes that point very clearly. For patients suffering from a rare disease, orphan drugs and the special attention that they receive during the drug review and approval process can be both life changing and saving.
English
Chinese
