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The question is often raised as to when to choose a bromobutyl- versus a chlorobutyl-based component. The answer is – it depends. They are comparable in terms of permeability for oxygen and water. Primary differences will be found in their extractables profiles, as different compounds are employed for curing, stabilization, etc.
Given the very wide range of drug products (small molecule, biologic, gene, cell) and the very wide range of possible chemical interactions with extractables, the best approach to select the right component is through consultation with a Technical Customer Support (TCS) expert at West. Recommendations are based upon extensive product knowledge and the ability to offer tailored experimental studies (e.g., extractables and leachables) through the Integrated Solutions offering, while also keeping patient safety as the most important goal.
For more information, contact a TCS representative or Account Manager.