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As drug manufacturers aim for higher safety standards and enhanced patient care, controlling the drug product at the point-of-use in a hospital or clinical environment remains a significant challenge. The method of vial access often varies, increasing the risk of adverse patient outcomes, such as stopper cores or fragments entering the drug product. If injected, these fragments can lead to cardiovascular events and other complications. Several factors contribute to stopper coring and fragmentation in the field, primarily influenced by the technique of the practitioner and the properties of the elastomeric closure.

Sanjeev Seenath

July 09, 2025

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Previous Blogs

West Launches New Product Innovations at Pharmapack 2020

By Mike Schaefers

February 06, 2020

Our team will share their expertise and introduce several new and innovative pharmaceutical containment and closure offerings during the Paris Pharmapack trade show.

Recommendations on Processing West Flip-Off® Seals

By Jia Min Boo

April 25, 2018

Customers frequently ask: Do we need to wash secondary closures, such as West Flip-Off^® seals? Like so many questions, the answer is “it depends”. But in general, the answer is “no”.

West Flip-Off® Seal Technologies: Enhanced Production and Consistent Button Removal

By Simon Meurer

December 11, 2017

Uninterrupted production on a high-speed filling line is a challenge. To help make this easier, West has developed Flip-Off^® seals. Flip-Off seals are produced with the highest quality aluminum and plastic materials, and the TruEdge^® manufacturing process.

West Flip-Off® Seals – A Diverse Portfolio

By JiaMin Boo

August 03, 2017

The right seal is essential for proper drug product vial closure. West offers a wide range of Flip-Off^® seal (FOS) products to meet customers’ varying requirements. Three grades are available for crimping needs in varying environments:

Standard Flip-Off^® seals: for consistent, reliable crimping outside controlled environments
Flip-Off^® Plus seals: for clean crimping under grade A air supply
Flip-Off^® Clean, Certified, Sterilized (CCS) seals: for aseptic crimping inside grade A environments.

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Films and Coatings

Pharmaceutical Packaging Components

Prefillable Systems

Self Injection Devices

Vial Containment Solutions

Washing and Sterilization

Reconstitution and Transfer Devices

Select a sub-category to view results

Analytical Lab Services

Contract Manufacturing

Fill-Finish

Regulatory Support

Select a sub-category to view results

Cell and Gene Therapy Packaging

Drug Development Process

Regulatory Challenges

Transitioning to Combination Products

Select a sub-category to view results

Corporate Development

ESG/Sustainability

One West Team (Employee Culture)

Our Culture of Giving (Philanthropy)

Research and Development