Effect of Closure Composition and Processing Parameters on End Product Dryness over Time

This study evaluates the amount of moisture in vials with closures subjected to varying wash and sterilization/drying cycles.

Residual moisture in elastomeric closures can cause degradation of lyophilized drug product. Prior to packaging the drug product, pharmaceutical manufacturers typically wash, steam sterilize and dry the closures. This sterilization process drives moisture into the closure.

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