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Delivery Systems

Drug product delivery systems can provide comfort, ease of use and reliability—especially automated systems like West’s SmartDose® platform. This section presents papers on manual and automated delivery systems and trends in this rapidly-growing area.

Putting Patients First:  Innovating Drug Containment and Delivery. 

C. Henshall.  ONDRUGDELIVERY.COM, 10-14 (2017)


This article reviews the benefits of wearable delivery devices – in particular the West SmartDose® product. 

Link: http://www.ondrugdelivery.com/publications/75/West.pdf

Device Training and Onboarding Considerations for On-Body Delivery Systems. 
J. Reynolds.  ONdrugDelivery.com, 78, 44-46 (September 2017)


This article discusses the importance of training in helping patients effectively use on-body drug delivery systems.

Link: https://www.ondrugdelivery.com/publications/78/Noble.pdf

Plastic Prefilled Syringes: A Better Fit for Autoinjector Systems. 
D. Stout and V. Vilavalam.  Pharmaceutical Technology, Volume 2009 Supplement 6, (November 2009)


This article discusses the benefits of pre-filled syringes based on Daikyo Crystal Zenith® cyclic olefin polymer (COP) – in terms of consistent performance and reducing the risk of interaction with drug product.

Link: http://www.pharmtech.com/plastic-prefilled-syringes-better-fit-autoinjector-systems

Optimizing the Bioavailability of Subcutaneously Administered Biotherapeutics Through Mechanochemical Drivers.
D.S. Collins, et al.  Pharmaceutical Research (2017) (on-line, https://doi.org/10.1007/s11095-017-2229-9)


This article discusses the factors that affect the transport and biodistribution of drug products in the subcutaneous space, and how parenteral delivery may offer benefits versus intravenous delivery.

Link: https://link.springer.com/article/10.1007/s11095-017-2229-9

Pre-filled syringes:  a review of the history, manufacturing and challenges. 

G. Sacha, et al.  Pharmaceutical Development and Technology, 20 (1), 1-11 (2015)


This is an excellent review of the development of pre-filled syringes, and the benefits they provide.  Included is a discussion of materials of construction, including polymer-based products (e.g., with Daikyo Crystal Zenith® cyclic olefin polymer)

Link: http://www.tandfonline.com/doi/full/10.3109/10837450.2014.982825

Drug Delivery & Formulation 2016 in Review

Josef Bossart, Ph. D., PharmaCircle LLC


This presentation discusses trends in the drug pipeline – in particular the influence of biologic drug products.  Necessarily coupled to biologic drug products is the need for injection technologies that facilitate ease of use, and compliance. Consideration of injection technologies must be made early in the drug product development process to ensure the ability to successfully deliver products.

Link: Bossart PharmaCircle Presentation DCAT 2017-03-22

 Drug Delivery Systems for Biopharmaceuticals. 

A. Siew.  BioPharm International, 28 (8), 14-19 (2015)


In this article, industry experts discuss the merits of pre-filled syringes and automated delivery systems.

Link: http://www.biopharminternational.com/drug-delivery-systems-biopharmaceuticals?pageID=2

Injecting Highly Viscous Drugs

A. Fry.  Pharmaceutical Technology, 38 (11) (2014)


This article discusses the issues in delivering highly viscous parenteral drug products, such as biologics.

Link: http://www.pharmtech.com/injecting-highly-viscous-drugs