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By Manfai Lee, PhD, George M Rodgers, MD, PhD, Randy Y Adachi, PhD

June 25, 2014

Manfai Lee, PhD1, George M Rodgers, MD, PhD1, Randy Y Adachi, PhD2

1Division of Hematology and Hematologic Malignancies, University of Utah Health Sciences Center, Salt Lake City, UT   2West Pharmaceutical Services, Inc., Scottsdale, AZ

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By Lloyd Waxman and Vinod Vilivalam

June 18, 2014

The use of proteins as therapeutics has focused attention on the need to maintain the stability of these labile molecules during both storage and shipment. The trend in the pharmaceutical industry has been to package therapeutic proteins in prefillable syringes made of glass. However, some biologics are not stable in glass syringes due to sensitivity to adhesives used in their manufacture and to tungsten oxides generated during needle placement.