Drug product delivery systems can provide comfort, ease of use and reliability—especially automated systems like West’s SmartDose® platform. This section presents papers on manual and automated delivery systems and trends in this rapidly-growing area.
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The intention of this study was to analyze and compare the functionality of two West plungers - the steam sterilized 1mL Long NovaPure plunger in 4023/50, and the Article 2340 plunger in 4023/50 Gray gammairradiated – with prefilled and empty syringes by examining break loose and extrusion profiles after up to 24 months of storage.
Discusses how selecting the right plunger product for your delivery system can avoid costly issues such as particle contamination, high levels of leachables forming during long term storage, and poor dose delivery performance.
This presentation covers: trends in Biologic drug delivery; the key factors to consider when selecting a containment and delivery system; ways to improve patient outcomes; and case studies and examples regarding container selection, self-Injection systems, and training and connectivity.
This presentation covers: market trends for prefilled containers and administration; why drug manufacturers are moving to polymer systems; and developing a polymer prefilled presentation for a new drug.
<p>This article discusses the importance of training in helping patients effectively use on-body drug delivery systems.</p>
<p><em>J. Reynolds. ONdrugDelivery.com, 78, 44-46 (September 2017)</em></p>
<p>This article discusses how connecting self-injection delivery systems such as West’s SmartDose® injector with smartphone apps (and training, education, rewards) can help increase adherence and improve outcomes.</p>
<p><em>C. Evans. Drug Development & Delivery, 18 (1) (January/February 2018)</em></p>
This article discusses the factors that affect the transport and biodistribution of drug products in the subcutaneous space, and how parenteral delivery may offer benefits versus intravenous delivery.
<p><em>D.S. Collins, et al. Pharmaceutical Research (2017) (on-line, https://doi.org/10.1007/s11095-017-2229-9) </em></p>
This article discusses the benefits of pre-filled syringes based on Daikyo Crystal Zenith® cyclic olefin polymer (COP) – in terms of consistent performance and reducing the risk of interaction with drug product.
<p><em>D. Stout and V. Vilavalam. Pharmaceutical Technology, Volume 2009 Supplement 6, (November 2009)</em></p>
<p>This is an excellent review of the development of pre-filled syringes, and the benefits they provide. Included is a discussion of materials of construction, including polymer-based products (e.g., with Daikyo Crystal Zenith® cyclic olefin polymer)</p>
<p ><em>G. Sacha, et al. Pharmaceutical Development and Technology, 20 (1), 1-11 (2015)</em></p>