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Material Properties

Suitability of a container/delivery system for a drug product depends upon the chemical/physical properties of the system’s materials of construction (glass, polymer, elastomer)—such as interaction with drug product, gas permeability and durability through temperature cycles. This section presents papers on these and similar topics.

Characterization of a Cyclic Olefin Polymer Microcentrifuge Tube. 
L. Waxman, et al.  BioTechniques, 62 (5), 223-228 (May 2017)


This article examines the performance of microcentrifuge tubes comprising Daikyo Crystal Zenith® cyclic olefin polymer to those comprising polypropylene.  Cyclic olefin polymer tubes perform as well, with the added benefit of a lower extractables profile.

Link: https://www.biotechniques.com/BiotechniquesJournal/2017/May/Characterization-of-a-cyclic-olefin-polymer-microcentrifuge-tube/biotechniques-365881.html

When Glass Vials Fail At Low Temperatures, Consider A Cyclic Olefin Polymer System. 
W. Winters.  Pharmaceutical Online (July 25, 2017)


This article describes the many benefits of Daikyo Crystal Zenith® cyclic olefin polymer versus glass for low-temperature storage of drug products.

Link: https://www.pharmaceuticalonline.com/doc/when-glass-vials-fail-at-low-temperatures-consider-a-cyclic-olefin-polymer-system-0001?immediate=true

Container system for enabling commercial production of cryopreserved cell therapy products. 
E. Woods, et al.  Regen. Med., 5 (4), 659-667 (2010)


This article demonstrates that vials comprising Daikyo Crystal Zenith® cyclic olefin polymer are well-suited to cryogenic storage/transport of cell therapy products.

Link: https://www.ncbi.nlm.nih.gov/pubmed/20632866

Evaluation of CZ-resin vials for packaging protein-based parenteral formulations.
S.S. Quadry, et al.  International Journal of Pharmaceutics, 252 (1-2), 207-212 (2003)


This article demonstrates that compared to glass, vials comprising Daikyo Crystal Zenith® cyclic olefin polymer provide for significantly less protein binding – and therefore are a viable alternative to glass for biologic drug product packaging/delivery.

Link: http://www.sciencedirect.com/science/article/pii/S0378517302006415

Activation energies of diffusion of organic migrants in cyclo olefin polymer. 
F. Welle.  International Journal of Pharmaceutics, 473, 510-517 (2014)


Discussed is the diffusion of selected organic compounds through cyclic olefin polymer - permeability coefficients are correlated with molecular volume and activation energy of diffusion.

Link: http://www.sciencedirect.com/science/article/pii/S0378517314005286

New Cyclic Olefins. 
Jon H. Schut


This article discusses some of the fundamental properties of cyclic polyolefins, i.e., polymers and co-polymers comprising norborene (bicyclo[2.2.1]hept-2-ene) and ethylene.

Link: http://www.ptonline.com/articles/new-cyclic-olefins

Synthesis of High Performance Cyclic Olefin Polymers (COPs) with Ester Group via Ring-Opening Metathesis Polymerization. 
J. Cui, et al.  Polymers 7 (8), 1389-1409 (2015)


This articles discusses the chemistry of polymerization of cyclic olefin polymers by ring-opening metathesis.

Link:  http://www.mdpi.com/2073-4360/7/8/1389

The Preferred Container Material for Parenteral Pharmaceutics. 


This article briefly compares the benefits of cyclic olefin polymers to glass in container/delivery syustems for parenteral drug products.

Link: http://www.chemtech-online.com/P&B/Claudia_oct12.html

Olefin Metathesis. 
R.H. Grubbs.  Tetrahedron 60, 7117–7140 (2004)


This is a review article on ring-opening olefin metathesis polymerization by R.H. Grubbs (California Institute of Technology), 2005 Nobel Laureate in Chemistry.  This type of polymerization is employed in the production of cyclic olefin polymers.

Link:  http://athena.uwindsor.ca/users/j/jlichaa/reference.nsf/6d8ffcfd02afe81e8525730600490ed8/10ff8b04ff3a317885256d88005720f6/$FILE/tet-2004-60-7117%20metathesis%20grubbs.pdf