Previous Blogs

Envision Verification Process

By Gabrielle Gehron

January 11, 2022

Automation is quickly becoming a major part of the world in which we live. From consumer applications like microwaves and automobiles, to use in large-scale factories that produce everything from dollar-store hair accessories to autopilot-driven aircrafts, automation surrounds us. This is a good thing – the products we use benefit from the increased quality, consistency, and productivity provided by automated systems. 

Fill-Finish Equipment

By Erik Anderson

October 21, 2021

The need for advanced containment solutions, and novel fill-finish processing to enable implementation of these solutions, continues to grow as more complex drug products enter multiple pipelines. As biotech companies develop these complex drug products, the integration of product and process knowledge is crucial to delivering product safety, quality, identity, potency, and purity. And as biotech companies seek partners to help accelerate their development processes, West is committed to leading multi-disciplined, high-performance teams in developing optimal fill-finish solutions for novel packaging and container systems. This dynamic partnership is well-illustrated by the following case study.

CZ Syringe and Vial with patient and nurse

By Lynn Yao

December 28, 2020

A parenteral drug product contaminated by particles is a potential health threat. In the bloodstream, particles can cause serious issues, such as capillary occlusion and immunogenic responses. In most cases, the observation of particles in a drug product leads to a recall.

Cell and Gene Therapy

By Page McAndrew, PhD

September 04, 2020

Gene therapies are stored and shipped at ultra-low temperature (approximately -80oC, either in a refrigerator or on dry ice). This provides a challenge to the primary package systems in maintaining container closure integrity (CCI), especially systems comprising glass vials and elastomer stoppers. These materials have different coefficients of thermal expansion. Upon cooling from room temperature to ultra-low temperature, they contract at different rates; this may lead to gaps and CCI loss.

Stoppers and Plungers

By Olga Laskina, Ph.D.

July 10, 2020

The overall quality of a final drug product depends on the components of its packaging and delivery systems.  The use of visually inspected components reduces the risk of defective components and helps ensure patient safety.

Coronavirus

By Page McAndrew PhD.

May 22, 2020

Developing a SARS-CoV-2 vaccine presents numerous and unprecedented challenges; prominent among them are greatly accelerated timelines. Ordinarily for a new drug product, there is sufficient time for selection/evaluation of the vial/stopper packaging system – one that guarantees quality and safety from manufacture through delivery. This is not the case for a SARS-CoV-2 vaccine where the primary packaging system must be chosen quickly, creating a higher risk.